BMS-587101

小分子

BMS-587101

B647972-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research. In Vitro BMS-587101 is a moderately potent inhibitor of LFA-1-mediated T-cell proliferation, with an IC 50 of 20 nM in human HUVEC cells. BMS-587101 inhibits LFA-1-mediated adhesion of T cells to endothelial cells, T cell proliferation, and Th1 cytokine production . In mouse splenocytes and a mouse ICAM-1 expressing cell lines, bEND, BMS-587101 shows inhibitory activities, with an IC 50 of 150 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In the mouse ovalbumin-induced lung inflammation model, BMS-587101 (0.1 mg/kg, 1.0 mg/kg, and 10 mg/kg; po.; twice a day) treatment significantly inhibits eosinophil accumulation . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

BMS-587101 是一种有效的口服活性白细胞功能相关抗原-1（LFA-1）拮抗剂。BMS-587101 具有抗炎作用，可用于类风湿性关节炎研究。

509083-77-6

C26H20Cl2N4O4S

555.43 g/mol

11635371

CN1C(=O)N(C(=O)[C@]12CN(C[C@H]2C3=CC=C(C=C3)C#N)CC4=CC(=CS4)C(=O)O)C5=CC(=CC(=C5)Cl)Cl

CN1C(=O)N(C(=O)[C@]12CN(C[C@H]2C3=CC=C(C=C3)C#N)CC4=CC(=CS4)C(=O)O)C5=CC(=CC(=C5)Cl)Cl

11635371

DMSO : 260 mg/mL (468.11 mM; Need ultrasonic)

1

7

5

554.058 Da

554.058 Da

133.000 Ų

37

0

975

0

1

1.7