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名称

Boc-Leu-Gly-Arg-AMC

别名

Boc-亮氨酸-甘氨酸-精氨酸-AMC

英文名称

Boc-Leu-Gly-Arg-AMC

货号

B648858-50mg

包装规格

50mg

浓度

≥98%

储存温度

避光,干燥,-80℃储存

运输条件

超低温冰袋运输

产品介绍

Boc-Leu-Gly-Arg-AMC is a fluorogenic AMC substrate for the convertases. Boc-Leu-Gly-Arg-AMC can be used in enzymatic assays. In Vitro To demonstrate the presence in the abdominal gland of proteolytic enzymes capable of generating Sodefrin, an enzymatic assay was developed using Boc-Leu-Gly-Arg-AMC as synthetic substrate. A crude extract of the abdominal gland hydrolyzed Boc-Leu-Gly-Arg-AMC to liberate 7-amino-4- methylcoumarin, suggesting that enzymes that generate sodefrin from its precursor molecule are present in the gland. The activity in the extract for cleaving Boc-Leu-Gly-Arg-AMC is optimal at pH 9.0 and 45 ℃. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

Boc-Leu-Gly-Arg-AMC 是转化酶的含氟 AMC 底物。Boc-Leu-Gly-Arg-AMC 可用于酶测定。

CAS号

65147-09-3

分子式

C29H43N7O7

分子量

601.69 g/mol

PubChem编号

53765602

Isomeric SMILES

CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C

IIUPAC Name

tert-butyl N-[(2S)-1-[[2-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]carbamate

INCHI

1S/C29H43N7O7/c1-16(2)12-21(36-28(41)43-29(4,5)6)25(39)33-15-23(37)35-20(8-7-11-32-27(30)31)26(40)34-18-9-10-19-17(3)13-24(38)42-22(19)14-18/h9-10,13-14,16,20-21H,7-8,11-12,15H2,1-6H3,(H,33,39)(H,34,40)(H,35,37)(H,36,41)(H4,30,31,32)/t20-,21-/m0/s1

InChi Key

DLAQYOHJZUTWDJ-SFTDATJTSA-N

Smiles

CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CCCN=C(N)N)NC(=O)CNC(=O)C(CC(C)C)NC(=O)OC(C)(C)C

PubChem CID

53765602

溶解性

DMSO : 100 mg/mL (166.20 mM; Need ultrasonic) H2O : <0.1 mg/mL (insoluble)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

601.322 Da

单同位素质量Monoisotopic Mass

601.322 Da

拓扑极表面积Topological Polar Surface Area

216.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

1080.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

1.400

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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