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Product details

名称

(Rac)-BRD0705

英文名称

(Rac)-BRD0705

货号

B649064-5mg

包装规格

5mg

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC 50 of 66 nM and a K d of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC 50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML). Form:Solid

生化机理

(Rac)-BRD0705 是 BRD0705 活性较低的外消旋体。BRD0705 是一种强效、具有对位表选择性和口服活性的 GSK3α 抑制剂，其 IC 50 为 66 nM，K d 为 4.8 μM。与 GSK3β 相比，BRD0705 对 GSK3α 的选择性提高了 8 倍（IC 50 为 515 nm）。

CAS号

1597440-03-3

分子式

C20H23N3O

分子量

321.42 g/mol

PubChem编号

136980454

IIUPAC Name

4-ethyl-7,7-dimethyl-4-phenyl-1,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one

INCHI

1S/C20H23N3O/c1-4-20(13-8-6-5-7-9-13)14-12-21-23-18(14)22-15-10-19(2,3)11-16(24)17(15)20/h5-9,12H,4,10-11H2,1-3H3,(H2,21,22,23)

InChi Key

NCKLQXXBRWCYMA-UHFFFAOYSA-N

Smiles

CCC1(C2=C(NC3=C1C(=O)CC(C3)(C)C)NN=C2)C4=CC=CC=C4

PubChem CID

136980454

溶解性

DMSO : 250 mg/mL (777.80 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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