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名称

Brofaromine

分子类型

小分子

别名

溴法罗明

英文名称

Brofaromine

货号

B649069-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Brofaromine (CGP 11305A) is a monoamine oxidase ( MAO ) inhibitor with IC 50 of 0.2 μM for MAO-A . In Vitro In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC 50 is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC 50 range of Brofaromine is 0.01 μM to 0.1 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.2 μM (MAO-A)

生化机理

布罗法罗明（CGP 11305A）是一种单胺氧化酶（MAO）抑制剂，对 MAO-A 的 IC 50 为 0.2u2009μM。

CAS号

63638-91-5

分子式

C14H16BrNO2

分子量

310.19 g/mol

PubChem编号

44571

Isomeric SMILES

COC1=CC(=C2C(=C1)C=C(O2)C3CCNCC3)Br

Smiles

COC1=CC(=C2C(=C1)C=C(O2)C3CCNCC3)Br

PubChem CID

44571

溶解性

DMSO : 250 mg/mL (805.96 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

309.036 Da

单同位素质量Monoisotopic Mass

309.036 Da

拓扑极表面积Topological Polar Surface Area

34.400 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

283.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.100

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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