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名称

BRD5648

英文名称

BRD5648

货号

B649456-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

BRD5648 ((R)-BRD0705) is a negative control of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC 50 of 66 nM and a K d of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC 50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML). In Vitro BRD5648, the inactive enantiomer of BRD0705, does not induce changes in enzyme phosphorylation or total β-catenin protein stabilization. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

BRD5648 （(R)-BRD0705）是 BRD0705 的阴性对照品。BRD0705 是一种强效、具有旁路选择性和口服活性的 GSK3α 抑制剂，其 IC 50 为 66 nM，K d 为 4.8 μM。与 GSK3β 相比，BRD0705 对 GSK3α 的选择性更高（8 倍）（IC 50 为 5.8 μM）。

CAS号

2056261-42-6

分子式

C20H23N3O

分子量

321.42 g/mol

PubChem编号

136980414

IIUPAC Name

(4R)-4-ethyl-7,7-dimethyl-4-phenyl-1,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one

INCHI

1S/C20H23N3O/c1-4-20(13-8-6-5-7-9-13)14-12-21-23-18(14)22-15-10-19(2,3)11-16(24)17(15)20/h5-9,12H,4,10-11H2,1-3H3,(H2,21,22,23)/t20-/m1/s1

InChi Key

NCKLQXXBRWCYMA-HXUWFJFHSA-N

Smiles

CCC1(C2=C(NC3=C1C(=O)CC(C3)(C)C)NN=C2)C4=CC=CC=C4

PubChem CID

136980414

溶解性

DMSO : 300 mg/mL (933.36 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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