BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC 50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC 50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain In Vitro BMT-090605 hydrochloride shows AAK1inhibitory activity with an IC 50 of 0.63 nM. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC 50 values of 45 nM and 60 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo BMT-090605 hydrochloride(intrathecal; 0.3-3 µg/rat) causes antinociception by inhibiting AAK1 in the spinal cord . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (chronic constriction injury (CCI) model) Dosage: 0.3-3 µg/rat Administration: Intrathecal Result: Caused a dose-dependent reduction in thermal hyperalgesia. Form:Solid IC50& Target:IC50: 0.6 nM (AAK1),45 nM (BIKE),60 nM (GAK)