Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. In Vitro Budesonide is selective for human glucocorticoid receptor (hGR; EC 50 =45.7 pM) over mineralocorticoid receptors (EC 50 =7,620 pM) in CV-1 cells. Budesonide (30 min prior to LPS) suppresses the activation of the NLRP3 inflammasome by LPS (100 ng/mL) plus ATP (5 mM) in macrophages (RAW 264.7 cells). MCE has not independently confirmed the accuracy of these methods. They are for reference only.