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Product introduction

BI-3663 is a highly selective PTK2 / FAK PROTAC ( DC 50 =30 nM), with Cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC 50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 linked to Pomalidomide with a linker Anti-cancer activity In Vitro BI-3663 potently degrades PTK2 in Hep3B2.1-7 cells, and A549 cells, with pDC 50 s of 7.6 and 7.9, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PTK2/FAK 18 nM (IC 50 ) Cereblon

Specs ⸢ View details ⸥

Chinese name

BI-3663

English name

BI-3663

Chinese alias

English alias

CAS number

2341740-84-7

molecular formula

C44H42F3N7O12

molecular weight

917.84 g/mol

Exact mass

≥99%

PSA

243.000 Å²

Logp

2.900

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