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Product details

名称

BAZ1A-IN-1

分子类型

未知

英文名称

BAZ1A-IN-1

货号

B651103-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a K D value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A , but weak or no activity against cancer cells with a low expression level of BAZ1A In Vitro BAZ1A-IN-1 (Cpd-2) (0.015-100 ?μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC 50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: THP-10 (leukemia), ZR-75-30 (breast cancer), BT474 (breast cancer), H1975 (lung cancer) cells Concentration: 0.015-100 μM Incubation Time: 96 hours Result: Significantly inhibited the viability activity in four cancer cell lines which all expressed high levels of BAZ1A. Form:Solid IC50& Target:BAZ1A

生化机理

BAZ1A-IN-1 是一种有效的 BAZ1A（含溴结构域蛋白）抑制剂。BAZ1A-IN-1 对 BAZ1A 含溴结构域的 K D 值为 0.52 μM。BAZ1A-IN-1 对表达高水平 BAZ1A 的癌细胞株具有良好的抗活活性，但对表达低水平 BAZ1A 的癌细胞株的抗活活性较低。

CAS号

941521-45-5

分子式

C16H12N4O3S

分子量

340.36 g/mol

Smiles

O=C(NC1=CC=CC([N+]([O-])=O)=C1)NC2=NC(C3=CC=CC=C3)=CS2

溶解性

DMSO : 25 mg/mL (73.45 mM; ultrasonic and warming and heat to 60°C)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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