BSH-IN-1

BSH-IN-1

B651381-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases ( BSH s) with IC 50 s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively. In Vitro BSH-IN-1 (Compound 7) also inhibits BSH activity in growing cultures of Gram-negative ( B. theta VPI-5482, Bacteroides fragilis ATCC 25285, and Bacteroides vulgatus ATCC 8482) and Gram-positive ( Lactobacillus plantarum WCFS1, C. perfringens ATCC 13124, and Bifidobacterium adolescentis L2-32) bacteria. BSH-IN-1 (Compound 7) also is a potent BSH inhibitor in growing bacterial cultures with IC 50 s of 237 nM and 1070 nM for B. adolescentis (Gram positive) and B. theta (Gram negative), respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo BSH-IN-1 (Compound 7; 10 mg/kg; a single dose; gavage) inhibits BSH activity in C57BL/6 mice and can be gut-restricted . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 mice Dosage: 10 mg/kg Administration: Single gavage Result: Inhibited gut bacterial BSH activity and modulated the bile acid pool in vivo while not significantly affected the gut bacterial community. Form:Solid

BSH-IN-1 是一种强效的肠道细菌重组胆盐水解酶（BSH s）共价抑制剂，对长殖菌 BSH（革兰氏阳性）和 B. theta BSH（革兰氏阴性）的 IC 50 s 分别为 108 nM 和 427 nM。

2553217-91-5

C25H41FO3

408.59 g/mol

145713829

(5R)-5-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-1-fluorohexan-2-one

1S/C25H41FO3/c1-15(4-5-18(28)14-26)19-6-7-20-23-21(9-11-25(19,20)3)24(2)10-8-17(27)12-16(24)13-22(23)29/h15-17,19-23,27,29H,4-14H2,1-3H3/t15-,16+,17-,19-,20+,21+,22-,23+,24+,25-/m1/s1

XDVGNIBMZHDZLL-GDQMVUAZSA-N

CC(CCC(=O)CF)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

145713829

DMSO : 25 mg/mL (61.19 mM; ultrasonic and warming and heat to 80°C)