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名称

BMS-986242

英文名称

BMS-986242

货号

B655039-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 ( IDO1 ) inhibitor. BMS-986242 can be used for the research of cancer In Vitro BMS-986242 is more prone to oxidative metabolism and less susceptible to glucuronidation. BMS-986242 shows IC 50 >25 μM for all targets except nAChR a1 (IC 50 =12.3 μM) and nAChR a7 (IC 50 >6 μM with ∼20 % max inhibition). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) exhibits dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: nu/nu Mouse Dosage: 3~30 mg/kg Administration: P.o. Result: Exhibited dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses. IC50& Target:IDO1

生化机理

BMS-986242 是一种口服活性、强效和选择性的吲哚胺-2,3-二氧化酶 1（IDO1）抑制剂。BMS-986242 可用于癌症研究。

CAS号

1923844-48-7(DMSO)

分子式

C24H24ClFN2O

分子量

410.91 g/mol

Smiles

CC(C1CCC(CC1)C2=C3C=C(C=CC3=NC=C2)F)NC(=O)C4=CC=C(C=C4)Cl

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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