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Product details

名称

BAMB-4

英文名称

BAMB-4

货号

B655217-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

BAMB-4 (ITPKA-IN-C14) is a specific and membrane-permeable ITPKA inhibitor. BAMB-4 has high stability and membrane permeability and against the inositol-1,4,5-trisphosphate (InsP3) kinase activity of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA) with an IC 50 value of 20 μM. BAMB-4 can be used for the research of metastasis of lung cancer In Vitro BAMB-4 (0.3-40 μM) has ITPKA inhibiton effect with an IC 50 value of 37 μM. BAMB-4 (40 μM) inhibits InsP3 kinase activity with an IC 50 value of 20 μM. BAMB-4 (100 μM, overnight) has high specificity and the high cellular uptake. BAMP-4 (0, 10, 20 and 40 μM) shows increased K m and decreased V max. BAMP-4 (0-30 μM) is a mixed type inhibitor with respect to ATP and InsP3 and does not only affect binding of ATP but also binding of InsP3，which affects turnover of two substrate exhibit a higher inhibition specifcity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 37 μM (ITPKA),20 μM (InsP3 kinase)

生化机理

BAMB-4（ITPKA-IN-C14）是一种特异性、膜渗透性 ITPKA 抑制剂。 BAMB-4 具有很高的稳定性和膜渗透性，能抑制肌醇-1,4,5-三磷酸激酶 A（ITPKA）的肌醇-1,4,5-三磷酸激酶（InsP3）活性。

CAS号

891025-25-5(DMSO)

分子式

C15H12N2O2

分子量

252.27 g/mol

Smiles

CC1=CC=C(C=C1)C(=O)NC2=NOC3=CC=CC=C32

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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