BN82002 hydrochloride

BN82002 盐酸盐

BN82002 hydrochloride

B655525-1ml

1ml

10mM in DMSO

避光,干燥,-80℃储存

超低温冰袋运输

BN82002 hydrochloride is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. BN82002 hydrochloride inhibits CDC25A, CDC25B2, CDC25B3, CDC25C CDC25A, and 25C-cat with IC 50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 µM, respectively. BN82002 hydrochloride displays ~20-fold greater selectivity over CD45 tyrosine phosphatase In Vitro The effect of BN82002 on cell proliferation is evaluated in vitro on several human tumor cell lines. Menadione, which has been reported to inhibit cell proliferation, is used as a control. All of the examined cell lines are sensitive to BN82002 and Menadione in a concentration-dependent manner in the low micromolar range. The most sensitive is the pancreatic cancer cell line MIA PaCa-2 with an IC 50 of 7.2 μM, and the less sensitive cell line is the colon cancer HT-29 with an IC 50 of 32.6 μM. The range of activity is very similar to the one observed with menadione (5-15 μM). It is also showed that 50 μM BN82002 is a concentration that fully inhibits cell proliferation, the cell cycle distribution is only modestly affected with a slight decrease in S phase and an increase in cells containing both a G1 and a G2 DNA content, suggesting that the cells treated with BN82002 are arrested at various stages of the cell cycle. MCE has not independently confirmed the accuracy of these methods. They are for reference only. -liquid mixture IC50& Target:IC50: 2.4 μM (CDC25A), 3.9 μM (CDC25B2), 6.3 μM (CDC25B3), 5.4 μM (CDC25C), 4.6 μM (CDC25C-cat)

BN82002 盐酸盐是 CDC25 磷酸酶家族的一种强效、选择性和不可逆的抑制剂。BN82002 盐酸盐对 CDC25A、CDC25B2、CDC25B3、CDC25C CDC25A 和 25C-cat 均有抑制作用，IC 50 值分别为 2.4、3.9、6.3、5.4 和 4.6 µM。BN8

1049740-43-3(DMSO)

C19H26ClN3O4

395.88 g/mol

O=[N+]([O-])C1=CC=C(CCN(CC2=CC(N(C)C)=CC(OC)=C2O)C)C=C1.Cl