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Product details

名称

BAY 73-6691

分子类型

小分子

英文名称

BAY 73-6691

货号

B655841-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective PDE9A inhibitor In Vitro The BAY 73-6691 dose-dependently alleviates cell viability loss due to Aβ 25-35 treatment. It is found that when SH-SY5Y cells are cultured by Aβ 25-35 , a high degree of cell apoptosis is observed, while additional stimulation with BAY 73-6691 causes attenuation of cell apoptosis.? BAY 73-6691 dose-dependently attenuates oxidative stress induced by Aβ 25-35 , and BAY 73-6691 at 200 μg/mL almost neutralizes Aβ 25-35 -induced oxidative damage. The BAY 73-6691 attenuates Aβ 25-35 -induced increase of apoptosis cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo BAY 73-6691 dose-dependently improves the acquisition performance in the Aβ 25-35 -injected mice on days 7 to 10 (day 7, F (5,54) =65.153; day 8, F (5,54) =62.340; day 9, F (5,54) =37.529; day 10, F (5,54) =38.624; P IC50& Target:PDE9

生化机理

BAY 73-6691 （(R)-BAY 73-6691）是一种强效、脑穿透性和选择性 PDE9A 抑制剂。

CAS号

794568-92-6(DMSO)

分子式

C15H12ClF3N4O

分子量

356.73 g/mol

Smiles

CC(CC1=NC2=C(C=NN2C3=CC=CC=C3Cl)C(=O)N1)C(F)(F)F

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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