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Product details

名称

BAY-850

英文名称

BAY-850

货号

B656245-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC 50 of 166 nM. In Vitro BAY-850 competes with the binding of a mono-acetylated Histone H4 N-terminal peptide to ATAD2 BD with an IC 50 of 166 nM measured in TR-FRET assay. BAY-850 displaces the tetra-acetylated peptide with an IC 50 of 157 nM and a K D of 115 nM respectively. The unprecedented isoform selectivity of BAY-850 suggests a different mode of action to those exhibited by canonical BD inhibitors. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:ATAD2

生化机理

BAY-850 是一种强效且具有同工酶选择性的 ATPase 家族 AAA 含域蛋白 2（ATAD2）抑制剂，其 IC 50 为 166 nM。

CAS号

2099142-76-2(DMSO)

分子式

C38H44ClN5O3

分子量

654.24 g/mol

Smiles

CC1=CC=C(C=C1)C(C)NCC2=CC=C(O2)C3=CC(=C(C=C3OC)Cl)C(=O)NC(CC4=CC=C(C=C4)C#N)CNC5CCC(CC5)N

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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