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Product details

名称

BAY 73-1449, IP 受体拮抗剂

英文名称

BAY 73-1449

货号

B656694-1ml

包装规格

1ml

级别

Moligand™

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

BAY 73-1449 是一种选择性前列环素受体 (prostacyclin receptor, IP) 的拮抗剂，在人 HEL 细胞和大鼠 DRG 的 cAMP 分析中具有很高的效价 (IC50 值小于 0.1 nM)。BAY 73-1449 可用于降血压的研究。 BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP) , with high potency ( IC 50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 can be used in the research of lowering blood pressure In Vivo BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats . BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats . BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats (250-350 g) are ligated portal vein Dosage: 0.1, 1 mg/kg Administration: A single i.v. Result: Significantly reduced shunt flow without affecting mesenteric flow. IC50& Target:IP Receptor

生化机理

BAY 73-1449 是一种选择性前列环素受体（IP）拮抗剂，在人 HEL 细胞和大鼠 DRG 的 cAMP 试验中具有很高的效力（IC 50 小于 0.1 nM）。BAY 73-1449 可用于降血压研究。

CAS号

693790-96-4(DMSO)

分子式

C26H23N3O3

分子量

425.48 g/mol

Smiles

C1=CC=C(C=C1)CC(C(=O)O)NC2=NC=NC(=C2)C3=CC=C(C=C3)OCC4=CC=CC=C4

作用类型

拮抗剂

作用机制

IP 受体拮抗剂

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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