Belvarafenib TFA

贝伐非尼三氟乙酸

Belvarafenib TFA

B659018-5mg

5mg

Moligand™

≥99%

-20°C储存,干燥

超低温冰袋运输

Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC 50 s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv 600E and C-RAF respectively. Appearance:Solid IC50& Target:IC50: 56 nM(B-RAF), 7 nM(B-RAFv 600E ), 5 nM(C-RAF) . In Vitro:Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC 50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv 600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DD Biological Activity:Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC 50 s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv 600E and C-RAF respectively.

C25H17ClF4N6O3S

592.95 g/mol

O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C.OC(C(F)(F)F)=O