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Product details

名称

BTK inhibitor 18

别名

BTK抑制剂18

英文名称

BTK inhibitor 18

货号

B659062-5mg

包装规格

5mg

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

BTK inhibitor 18 is a potent, selective,orally active and covalent Btk inhibitor with a IC 50 of 142 nM. BTK inhibitor 18 has anti-inflammatory activities. IC50& Target:IC50: 142 nM (Btk) In Vitro:BTK inhibitor 18 (Compound 27) irreversibly inhibits BTK by targeting a noncatalytic cysteine residue (Cys481) for covalent bond formation. BTK inhibitor 18 (Compound 27) inhibits anti-IgM-induced activation of B cells in human whole blood with an IC In Vivo:BTK inhibitor 18 (Compound 27; 1-30mg/kg; oral administration; once a day; for 7 days) treatment shows dose-dependent efficacy at reducing joint inflammation in a rat collagen-induced arthritis model. The IV and PO pharmacokinetics of BTK inhibitor Biological Activity:BTK inhibitor 18 is a potent, selective,orally active and covalent Btk inhibitor with a IC 50 of 142 nM. BTK inhibitor 18 has anti-inflammatory activities.

分子式

C29H25N5O4S2

分子量

571.67 g/mol

Smiles

CC1=CC(OC2=CC=CC=C2)=CC=C1N3C4=C5C(NC3=O)=C(C(N[C@H]6CN(C(C=C)=O)CC6)=O)SC5=NC=C4.[*S]

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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