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Product introduction
镰刀菌酸是吡啶类和芳香族羧酸的一种。
Chinese name
镰孢菌酸
English name
5-butylpyridine-2-carboxylic acid
Chinese alias
5-丁基吡啶-2-羧酸 | 5-丁基皮考啉酸 | 萎蔫酸
English alias
5-Butylpyridine-2-carboxylic Acid | 5-Butylpicolinic Acid
CAS number
536-69-6
molecular formula
C10H13NO2
molecular weight
179.22
Exact mass
≥98%
PSA
50.2
Logp
2.6
Safety
  • Treatment: 那他霉素眼悬液是丝状真菌感染如真菌性角膜炎的首选药物。(L1964)
  • exposure pathway: 口服、皮肤接触、吸入和注射(受污染药物)。(A3101)
  • Toxicity summary: 镰刀菌酸通过作为酪氨酸羟化酶的部分抑制剂和多巴胺-β-羟化酶的抑制剂来影响神经递质水平。这已被证明会导致大脑中5-羟色胺、5-羟吲哚乙酸、酪氨酸和多巴胺水平升高,以及去甲肾上腺素水平降低。这些神经递质水平的变化可能导致低血压、行为和运动活动改变、神经系统障碍和发育问题等影响。(A3020, A3021, A3022, A3023)
  • interaction: 当给雄性小鼠在戒酒后6小时注射 Fusaric acid (100 MG/KG, IP) 后,4小时后大脑中去甲肾上腺素、多巴胺和血清素的浓度分别为112.8、186.4和652.8 NG/G。Fusaric acid 注射降低了大脑中去甲肾上腺素水平,同时加剧了酒精戒断综合征。
  • Health Effects: 镰刀菌酸可导致真菌性角膜炎感染。它还具有发育和神经毒性。(A3021, A3023)
  • Special Reports: 关于镰刀菌酸作为植物毒素作用的综述,含28篇参考文献。[KALYANASUNDARAM R;镰刀菌酸的作用机制;植物病害问题处理国际研讨会第一届:142(1970)]
  • Symptoms and Signs: 镰刀菌酸可引起呕吐、低血压以及行为和活动能力的改变。(A3020, A3022, A3023)
  • Hazard categories and classifications: 急性毒性 4 (98.6%)
  • Non-human toxic extract: 确定了多巴胺-β-羟化酶抑制剂镰刀菌酸(FA)在给予L-酪氨酸或平衡蛋白膳食补充剂后,剂量为3.2-60 MG/KG时对攻击性、运动活性及脑单胺类物质的影响。与生理盐水注射的对照组动物相比,高剂量的镰刀菌酸降低了攻击性和运动活性。在给予酪氨酸补充剂的动物中,30至60 MG/KG剂量的FA降低了脑去甲肾上腺素、多巴胺和脑酪氨酸。相反,FA增加了5-羟色胺,并在高剂量下引起5-羟吲哚乙酸显著增加。
  • Carcinogen Classification: 对人类无致癌性迹象(未被IARC列出)。
  • Natural Pollution Sources: 从尖镰孢菌(FUSARIUM OXYSPORUM F VASINFECTUM)的培养介质中分离出的毒素被鉴定为镰刀菌酸。
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upstream information
Manufacturing method:
FUSARIC ACID(化合物ID:3442);GLUCOSE(化合物ID:5793)
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5-butylpyridineformic acid 10mM in DMSO 1ml

Macklin 5-butylpyridineformic acid 10mM in DMSO 1ml, CAS 536-69-6, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:B689125-1ml
Product model:1ml
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