Lovastatin Hydroxy Acid钠盐是洛伐他汀的活性羧酸盐形式，是HMGCR的抑制剂（HMG-CoA还原酶）（酸形式的K | i为1 nM）。Lovastatin Hydroxy Acid在全细胞以及无细胞测定中均具有活性，并抑制胆固醇和类异戊二烯的生物合成。洛伐他汀还可以阻断蛋白质异戊二烯化，降低人体血浆胆固醇水平，并导致细胞在G | 1 |期早期停滞。 Lovastatin Hydroxy Acid, Sodium Salt is an active carboxylate form of Lovastatin , an inhibitor of HMGCR (HMG-CoA reductase) (K|i|for acid form is 1 nM). Lovastatin Hydroxy Acid, Sodium Salt is active in whole cells as well as cell-free assays and inhibits cholesterol and isoprenoid biosynthesis. Lovastatin also blocks protein isoprenylation, reduces plasma cholesterol levels in humans, and causes cells to arrest early in the G|1|phase.