12（S）-HPETE是通过血小板或白细胞12-脂氧合酶（12-LO）对花生四烯酸的作用而产生的单氢过氧多不饱和脂肪酸。它激活人血白细胞5-LO，从而合成5（S）-HETE，白三烯B4和5（S），12（S）-DiHETE。大鼠肺部将12（S）-HpETE代谢为8,11,12-和10,11,12-三羟基二十碳五烯酸。12（S）-HpETE是许多生物学功能的介体，包括c-fos和c-jun的诱导，AP-1的激活以及内皮依赖性血管收缩。它介导海兔感觉神经元对FMRF-酰胺的抑制性突触反应，并且是来自大鼠大脑皮层 12(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4, and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and is a potent and selective inhibitor of CaMKII (Ca|2+|/calmodulin-dependent protein kinase II) from rat brain cortex. Also inhibits TXA Synthase (thromboxane synthase) and platelet aggregation via activation of GCS (guanylate cyclase). 12(S)-HPETE is an activator of VR1.