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Product introduction

TDZD-8(NP 01139)是thiadiazolidinone的衍生物，是非ATP竞争性GSK-3β抑制剂，IC50为2 μM，对Cdk-1/cyclin B，CK-II，PKA和PKC无活性。TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program;TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb. TDZD-8(NP 01139) is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM); does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program;TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.

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Chinese name

4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮, 糖原合酶激酶 3 beta 抑制剂

English name

TDZD-8

Chinese alias

English alias

s2926 | 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)- | BDBM7781 | U3W | BCP07657 | A Inhibitor I; NP 01139 | A875545 | NCGC00165913-12 | AC-35779 | FS-2551 | GSK-3beta Inhibitor I - CAS 327036-89-5 | J-018843 | LS-13757 | TDZD8 | TDZD-8 | M

CAS number

327036-89-5

molecular formula

C10H10N2O2S

molecular weight

222.26 g/mol

Exact mass

PSA

65.900 Å²

Logp

1.500

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4-benzyl-2-methyl-1, 2, 4-thiadiazolealkane-3, 5-diketone 10mM in DMSO 1ml

Name: 4-benzyl-2-methyl-1, 2, 4-thiadiazolealkane-3, 5-diketone 10mM in DMSO 1ml
Brand: 麦克林
SKU: B793672-1ml

4-benzyl-2-methyl-1, 2, 4-thiadiazolealkane-3, 5-diketone 10mM in DMSO 1ml Macklin 327036-89-5, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number：B793672-1ml

Product model：1ml

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Lead Time：30days

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4-benzyl-2-methyl-1, 2, 4-thiadiazolealkane-3, 5-diketone 10mM in DMSO 1ml

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