Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

跨膜转运/离子通道

分子类型

小分子

别名

1-[2-[双[4-(三氟甲基)苯基]甲氧基]乙基] -1,2,5,6-四氢吡啶-3-羧酸盐酸盐

英文别名

AKOS024456513 | DTXSID30149193 | 1-(2-(Bis(4-(trifluoromethyl)phenyl)methoxy)ethyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride | 1-(2-(BIS(4-(TRIFLUOROMETHYL)PHENYL)METHOXY)ETHYL)-1,2,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLIC ACID MONOHYDROCHLOR

英文名称

CI 966 hydrochloride

货号

C286931-100mg

包装规格

100mg

浓度

≥98%(HPLC)

储存温度

室温,干燥

运输条件

常规运输

敏感性

对湿度敏感

产品介绍

CI-966 hydrochloride 是一种有效，选择性，具有口服活性和可透过血脑屏障的 GABA 转运蛋白 GAT-1 抑制剂，抑制 hGAT-1 和 rGAT-1 的 IC50 分别为 0.26 μM 和 1.2 μM。CI-966 hydrochloride 对 GAT-1 的选择性比 GAT-2，GAT-3 和 BGT-3 高 200 倍以上。CI-966 hydrochloride 具有抗惊厥和神经保护活性。

生化机理

GABA转运蛋白GAT-1的选择性抑制剂（克隆的人和大鼠GAT-1的IC50值分别为0.26和1.2μM）。与GAT-2和GAT-3相比，具有200倍的选择性。在体内全身给药时具有中枢活性。抗惊厥和神经保护。

CAS号

110283-66-4

分子式

C23H21F6NO3•HCl

分子量

509.87 g/mol

PubChem编号

198692

Isomeric SMILES

C1CN(CC(=C1)C(=O)O)CCOC(C2=CC=C(C=C2)C(F)(F)F)C3=CC=C(C=C3)C(F)(F)F.Cl

IIUPAC Name

1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid;hydrochloride

INCHI

1S/C23H21F6NO3.ClH/c24-22(25,26)18-7-3-15(4-8-18)20(16-5-9-19(10-6-16)23(27,28)29)33-13-12-30-11-1-2-17(14-30)21(31)32;/h2-10,20H,1,11-14H2,(H,31,32);1H

InChi Key

NUQWSOWKRTZJTO-UHFFFAOYSA-N

Smiles

C1CN(CC(=C1)C(=O)O)CCOC(C2=CC=C(C=C2)C(F)(F)F)C3=CC=C(C=C3)C(F)(F)F.Cl

PubChem CID

198692

关联CAS

110283-79-9

溶解性

溶于ethanol, 最高浓度 (mg/mL): None, 最高浓度(mM): 10；溶于DMSO, 最高浓度 (mg/mL): None, 最高浓度(mM): 100

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

509.119 Da

单同位素质量Monoisotopic Mass

509.119 Da

拓扑极表面积Topological Polar Surface Area

49.800 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

643.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！

Research chemical 100mg; ≥98%; HPLC

Name: Research chemical 100mg; ≥98%; HPLC
Brand: 阿拉丁
SKU: C286931-100mg

Research chemical 100mg; ≥98%; HPLC; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 100mg; ≥98%; HPLC.

item number：C286931-100mg

Product model：100mg

level： 100mg; ≥98%; HPLC

Lead Time：30days

sold 629 Items

Ask Solution engineer

Specifications：

100mg

Qty

Research chemical 100mg; ≥98%; HPLC

Recommended for you