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Product introduction

CW 008 是吡唑-吡啶的衍生物，是 CREB 或 PKA 途径激动剂。CW 008 也是一种干细胞分化剂。CW 008 可刺激人类 MSC 的成骨细胞分化，并增加卵巢切除小鼠的骨形成。CW008 通过激活 cAMP/PKA/CREB 信号通路、抑制瘦素分泌来促进成骨作用。 CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion

Specs ⸢ View details ⸥

Chinese name

CW 008,PKA信号激活剂

English name

CW 008

Chinese alias

4-氟-N-[5-氟-6-(5-甲氧基吡唑并[1,5-a]吡啶-3-基)-1H-吡唑并[3,4-b]吡啶-3-基]苯甲酰胺

English alias

4-Fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide

CAS number

1134613-19-6

molecular formula

C21H14F2N6O2

molecular weight

420.37 g/mol

Exact mass

PSA

97.200 Å²

Logp

3.000

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