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Product introduction
白屈菜红碱是从花椒、白屈菜和其他罂粟科植物根中分离出的苯并菲啶生物碱。它具有抗菌剂、抗肿瘤剂和EC 2.7.11.13(蛋白激酶C)抑制剂的作用。它是一种有机阳离子和苯并菲啶生物碱。
Chinese name
白屈菜红碱
English name
1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium
Chinese alias
-
English alias
1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
CAS number
34316-15-9
molecular formula
C21H18NO4+
molecular weight
348.4
Exact mass
-
PSA
40.8
Logp
4.6
Safety
  • Toxicity summary: 白屈菜红碱是一种强效、选择性且细胞渗透性的蛋白激酶C(PKC)抑制剂。它也是植物花椒(Zanthoxylum clava-herculis)中发现的主要活性天然产物,对金黄色葡萄球菌具有抗菌活性。(维基百科)白屈菜红碱是A组和B组PKC异构体的选择性抑制剂,具有抗肿瘤活性。使用白屈菜红碱氯化物抑制PKC可通过激活中性神经酰胺酶、神经酰胺积累和神经酰胺耗竭诱导细胞凋亡。白屈菜红碱对PKC的选择性比对其他激酶至少高100倍。白屈菜红碱与PKC的保守催化位点竞争,似乎是A组和B组激酶的强效特异性抑制剂。白屈菜红碱表现出细胞毒性...
  • Hazard categories and classifications: 眼刺激 2(50%)
  • Carcinogen Classification: 对人类无致癌性迹象(未被IARC列出)。
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Research chemical

Research chemical; supplied for laboratory research, analysis, inspection, and scientific procurement use.

item number:C303486-100mg
Product model:100mg
level:
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