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Product introduction

CUDA是可溶性环氧化物水解酶的抑制剂（sEH，小鼠中IC | 50 | = 11.1 nM）。研究表明，在COS-7细胞中，10 µM CUDA可以阻止94％的14,15-EET转化为14,15-DHET。CUDA以10 µM的浓度选择性地过氧化物酶体增殖物激活受体α（PPARα）活化8倍，而对PPARδ或PPARγ无影响。CUDA 可能对心血管疾病的研究有价值。 CUDA is an inhibitor of soluble epoxide hydrolase (sEH, IC|50|= 11.1 nM in mice). Studies have shown that 10 μM of CUDA can block the conversion of 14,15-EET to 14,15-DHET by 94% in COS-7 cells. CUDA selectively activates peroxisome proliferator-activated receptor α (PPARα) 8-fold at a concentration of 10 μM with no affect on PPARδ or PPARγ.CUDA may be valuable for the study of cardiovascular diseases.

Specs ⸢ View details ⸥

Chinese name

CUDA

English name

CUDA

Chinese alias

English alias

CAS number

479413-68-8

molecular formula

C19H36N2O3

molecular weight

340.50 g/mol

Exact mass

≥95%

PSA

78.400 Å²

Logp

5.000

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