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Product introduction

Canagliflozin (JNJ 28431754) 是一种选择性的 SGLT2 抑制剂，作用于表达 mSGLT2，rSGLT2 和 hSGLT2 的 CHO细胞，IC50 分别为 2 nM，3.7 nM 和 4.4 nM Canagliflozin inhibits Na+- dependent 14C-AMG uptake in a concentration-dependent fashion. It is a novel C-glucoside with thiophene ring.

Specs ⸢ View details ⸥

Chinese name

卡格列净, 钠/葡萄糖共转运体 1 抑制剂

English name

Canagliflozin

Chinese alias

English alias

JNJ 24831754ZAE | JNJ 28431754AAA | TA 7284 | JNJ 28431754 | (2S,3R,4R,5S,6R)-2-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

CAS number

842133-18-0

molecular formula

C24H25FO5S

molecular weight

444.52 g/mol

Exact mass

PSA

118.000 Å²

Logp

3.2

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