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Product details

名称

跨膜转运/离子通道

分子类型

未知

别名

4-氯-2-[[[2-(2-氯苯氧基)乙酰基]氨基]苯甲酸

英文名称

CBA

货号

C423565-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

TRPM4-IN-1 (CBA) 是一种有效的、选择性的阳离子通道 TRPM4 抑制剂，其 IC50 为 1.5 μM。TRPM4-IN-1 可用于心脏病和前列腺癌的研究。

生化机理

选择性TRPM4阻滞剂（IC50 = 1.5μM）。对TRPM5，TRPM7，TRPM8，TRPV1，TRPV3，TRPV6和一系列其他离子通道和受体没有显着活性。在体外显示出针对谷氨酸诱导的神经变性的神经保护作用。

CAS号

351424-20-9

分子式

C15H11Cl2NO4

分子量

340.16 g/mol

PubChem编号

2264067

Isomeric SMILES

C1=CC=C(C(=C1)OCC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O)Cl

IIUPAC Name

4-chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid

INCHI

1S/C15H11Cl2NO4/c16-9-5-6-10(15(20)21)12(7-9)18-14(19)8-22-13-4-2-1-3-11(13)17/h1-7H,8H2,(H,18,19)(H,20,21)

InChi Key

CVQCJPCMPGKEDH-UHFFFAOYSA-N

Smiles

C1=CC=C(C(=C1)OCC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O)Cl

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

339.007 Da

单同位素质量Monoisotopic Mass

339.007 Da

拓扑极表面积Topological Polar Surface Area

75.600 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

407.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.100

Reaxy-Rn

32871543

作用类型

通道阻滞剂

作用机制

TRPM4 通道阻断剂;TRPM4 通路抑制剂

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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