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Product introduction

Information Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) inhibits phosphorylation ofSTAT3,JNKandErk1/2, enhances the phosphorylation ofIκBandNF-κB, blocks nuclear translocation ofNF-κBand decreases mRNA levels ofIκBαandTNF-α. Cucurbitacin IIb exhibits anti-inflammatory activity and inducesapoptosis. Cucurbitacin IIb is isolated fromHemsleya amabilis. Targets STAT3 ; JNK ; ERK1/2 ; IκBα ; NF-κB 33577,

Specs ⸢ View details ⸥

Chinese name

雪胆素乙

English name

Cucurbitacin IIb

Chinese alias

English alias

(2S,3S,8S,9R,10R,13R,14S,16R,17R)-17-[(2R)-2,6-dihydroxy-6-methyl-3-oxoheptan-2-yl]-2,3,16-trihydroxy-4,4,9,13,14-pentamethyl-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-11-one | HY-N1987 | Curcurbitacin-Iib | Cucurbitacin centob | S0949 |

CAS number

50298-90-3

molecular formula

C30H48O7

molecular weight

520.71 g/mol

Exact mass

10mM in DMSO

PSA

135.000 Å²

Logp

2.000

Technical Documents

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