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Product introduction

环噻嗪是3,4-二氢-2H-1,2,4-苯并噻嗪1,1-二氧化物，在3、5和6位分别被2-降冰片烯-5-基、氯基和磺酰胺基取代。作为一种噻嗪类利尿剂，它已被用于治疗高血压和水肿。它具有利尿剂和降压剂的作用。

Specs ⸢ View details ⸥

Chinese name

环噻嗪, GluA1 的受体调节剂

English name

3-(2-bicyclo[2.2.1]hept-5-enyl)-6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

Chinese alias

English alias

6-Chloro-3，4-dihydro-3-(2-norbornen-5-yl)-2H-1，2-4-benzothiadiazine-7-sulfonamide 1，1-dioxide

CAS number

2259-96-3

molecular formula

C14H16ClN3O4S2

molecular weight

389.9

Exact mass

PSA

135

Logp

Safety

Disposal method： SRP：在审查时，土地处理或填埋(卫生填埋)处置实践的标准正在重大修订中。在实施废物残渣(包括废物污泥)的土地处置之前，咨询环境监管机构以获取可接受的处置实践指导。

Human toxicity extract：可能抑制泌乳，但与母乳喂养兼容/SRP：/。/来自表格/

Hazard categories and classifications：特定靶器官毒性 - 反复接触 - 1类(骨髓、心脏、肝脏、免疫系统、全身毒性)

Non-human toxic extract：可能出现钾耗竭。

Antidote and first aid：噻嗪类利尿剂过量应立即进行胃排空，然后进行支持性对症治疗，并监测血清电解质浓度和肾功能。/噻嗪类利尿剂/

Drug Induced Liver Injury：参考文献：DOI:10.1016/j.drudis.2019.09.022

Technical Documents

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upstream information

Manufacturing method：

3-氯苯胺(CID:7932); 氯磺酸(CID:24638); 氨(CID:222); 5-降冰片烯-2-甲醛(CID:95117)

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Consultation

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