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Product introduction
卡比沙明是一种有机氯化合物,是2-(4-氯苄基)吡啶,其中一个苄基氢被2-(二甲基氨基)乙氧基取代。它是一种乙醇类抗组胺药,以其马来酸盐形式用于治疗花粉热,以及轻度帕金森病。它具有H1受体拮抗剂、抗帕金森药物、毒蕈碱拮抗剂和抗过敏剂的功能。它是吡啶、三级胺化合物和一氯苯的成员。
Chinese name
卡比沙明
English name
2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine
Chinese alias
2-((4-氯苯基)(吡啶-2-基)甲氧基)-N,N-二甲基乙胺 | 2-((4-氯苯基)(吡啶-2-基)甲氧基)-N,N-二甲基乙胺
English alias
{2-[(4-Chlorophenyl)-2-pyridylmethoxy]ethyl}dimethylamine | BRN 0250475 | CARBINOXAMINE [MI] | KBio2_000520 | 2-[(4-chlorophenyl)-pyridin-2-yl-methoxy]-N,N-dimethyl-ethanamine | 2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine | Allergefon
CAS number
486-16-8
molecular formula
C16H19ClN2O
molecular weight
290.79
Exact mass
-
PSA
25.4
Logp
2.9
Safety
  • Toxicity summary: 卡比沙明与游离组胺竞争结合于组胺受体位点。这拮抗了组胺对组胺受体的作用,减少了组胺结合组胺受体带来的负面症状。卡比沙明的抗胆碱作用似乎是由于中枢抗毒蕈碱效应,这也可能是其止吐作用的原因,尽管确切机制尚不清楚。
  • Hepatotoxicity: 药物类别:抗组胺药
  • Carcinogen Classification: 对人类无致癌性迹象(未被IARC列出)。
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Effects During Pregnancy and Lactation: 注射相对高剂量的抗组胺药可降低非哺乳期妇女和产后早期妇女的基础血清催乳素。然而,产后母亲使用抗组胺药预处理不会影响哺乳引起的催乳素分泌。较低口服剂量的氯苯吡胺对血清催乳素是否有相同效果,或催乳素的变化对母乳喂养成功率是否有任何影响尚未研究。已建立哺乳的母亲体内的催乳素水平可能不会影响她的母乳喂养能力。
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Research chemical 5mg; ≥95%

Research chemical 5mg; ≥95%; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 5mg; ≥95%.

item number:C608317-5mg
Product model:5mg
level: 5mg; ≥95%
Lead Time:30days
sold 164 Items
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5mg

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