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Product details

名称

CMS-121

分子类型

小分子

英文别名

英文名称

CMS-121

货号

C646315-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC 50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities In Vitro CMS-121 (1 µM; 4 hours; HT22 cells) treatment increases the phosphorylation of ACC1 at serine 79. CMS-121 can increase acetyl-CoA in cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HT22 cells Concentration: 1 µM Incubation Time: 4 hours Result: Increases the phosphorylation of ACC1 at serine 79. In Vivo CMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female SAMP8 mice (9 months old) Dosage: ~20 mg/kg/day Administration: Oral administration; daily; for 4 months Result: Reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain. Form:Solid IC50& Target:Acetyl-CoA carboxylase 1 (ACC1)

生化机理

CMS-121 是一种喹诺酮衍生物，也是一种口服活性乙酰-CoA 羧化酶 1 (ACC1) 抑制剂。CMS-121 可保护 HT22 细胞免受缺血和氧化损伤，其 EC 50 值分别为 7 nM 和 200 nM。CMS-121 具有很强的神经保护和抗氧化作用。

CAS号

1353224-53-9

分子式

C20H19NO3

分子量

321.37 g/mol

PubChem编号

135741221

Isomeric SMILES

C1CCC(C1)OC2=CC(=NC3=CC=CC=C32)C4=CC(=C(C=C4)O)O

IIUPAC Name

4-(4-cyclopentyloxyquinolin-2-yl)benzene-1,2-diol

INCHI

1S/C20H19NO3/c22-18-10-9-13(11-19(18)23)17-12-20(24-14-5-1-2-6-14)15-7-3-4-8-16(15)21-17/h3-4,7-12,14,22-23H,1-2,5-6H2

InChi Key

OMHNVUCFPJJLKD-UHFFFAOYSA-N

Smiles

C1CCC(C1)OC2=CC(=NC3=CC=CC=C32)C4=CC(=C(C=C4)O)O

PubChem CID

135741221

关联CAS

1353224-53-9

溶解性

DMSO : 50 mg/mL (155.58 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

321.136 Da

单同位素质量Monoisotopic Mass

321.136 Da

拓扑极表面积Topological Polar Surface Area

62.600 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

412

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.4

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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