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Product details

名称

C75

分子类型

小分子

英文别名

英文名称

C75

货号

C646929-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

C75 is a synthetic fatty-acid synthase ( FASN ) inhibitor; inhibits prostate cancer cells PC3 with an IC 50 of 35 μM C75 is a potent CPT1A activator. In Vitro C75 inhibits PC3 cell growht with an IC 50 of 35 μM at 24 h. C75 (10-50 μM) also reduces the growth of LNCaP spheroids in a concentration-dependent manner with an IC 50 of 50 μM. (-)-C75 inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)-C75 inhibits CPT1 and its administration produces anorexia, suggesting that central inhibition of CPT1 is essential for the anorectic effect of C75. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 35 μM (PC3 cell)

生化机理

C75 是一种合成的脂肪酸合成酶（FASN）抑制剂；对前列腺癌细胞 PC3 的抑制作用 IC 50 为 35 μM。C75 是一种有效的 CPT1A 激活剂。

CAS号

218137-86-1

分子式

C14H22O4

分子量

254.32 g/mol

PubChem编号

4248455

Isomeric SMILES

CCCCCCCCC1C(C(=C)C(=O)O1)C(=O)O

IIUPAC Name

4-methylidene-2-octyl-5-oxooxolane-3-carboxylic acid

INCHI

1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)

InChi Key

VCWLZDVWHQVAJU-UHFFFAOYSA-N

Smiles

CCCCCCCCC1C(C(=C)C(=O)O1)C(=O)O

溶解性

DMSO : ≥ 83.3 mg/mL (327.54 mM) H2O : <0.1 mg/mL (ultrasonic) (insoluble)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

254.152 Da

单同位素质量Monoisotopic Mass

254.152 Da

拓扑极表面积Topological Polar Surface Area

63.600 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

322.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.000

Reaxy-Rn

9925444

RIDADR

NONHforallmodesoftransport

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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