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Product details

名称

Clitocine

分子类型

小分子

别名

克利托辛

英文别名

英文名称

Clitocine

货号

C647589-5mg

包装规格

5mg

浓度

≥95%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity. In Vitro Clitocine incorporation into mRNA is required for premature stop codon readthrough activity, and the presence of clitocine at the third position of a premature stop codon is sufficient to promote robust readthrough. Clitocine (0-0.8 μM; 24 hours) enhances TRAIL-lethality in in LS411N and SW620 cells. Clitocine (0.2μM; 36 hours) significantly potentiates TRAIL-mediated apoptosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Citocine (0.3-3 mg/kg; s.c.; five times per week)-induced p53 inhibits CAOV-33 p53-UAA136 tumor growth in a xenograft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: nu/nu mice (CAOV-3p53-UAA136 xenograft tumors) Dosage: 0.3, 3 mg/kg (or 20 mg/kg once per week) Administration: S.c.; five times per week Result: CAOV-33 p53-UAA136 tumor growth was inhibited. Form:Solid

生化机理

从蘑菇中分离出来的腺苷核苷类似物 Clitocine 是一种强效的突破性药物。Clitocine 可抑制无义突变，并能诱导携带 p53 无义突变等位基因的细胞产生 p53 蛋白。

CAS号

105798-74-1

分子式

C9H13N5O6

分子量

287.23 g/mol

PubChem编号

129111

Isomeric SMILES

C1=NC(=C(C(=N1)N[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)[N+](=O)[O-])N

IIUPAC Name

(2R,3R,4S,5R)-2-[(6-amino-5-nitropyrimidin-4-yl)amino]-5-(hydroxymethyl)oxolane-3,4-diol

INCHI

1S/C9H13N5O6/c10-7-4(14(18)19)8(12-2-11-7)13-9-6(17)5(16)3(1-15)20-9/h2-3,5-6,9,15-17H,1H2,(H3,10,11,12,13)/t3-,5-,6-,9-/m1/s1

InChi Key

OHEMBWZZEKCBAS-UUOKFMHZSA-N

Smiles

C1=NC(=C(C(=N1)NC2C(C(C(O2)CO)O)O)[N+](=O)[O-])N

PubChem CID

129111

关联CAS

105798-74-1

MeSH Entry Terms

6-amino-5-nitro-4-(ribofuranosylamino)pyrimidine;clitocine

溶解性

DMSO : 100 mg/mL (348.15 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

287.087 Da

单同位素质量Monoisotopic Mass

287.087 Da

拓扑极表面积Topological Polar Surface Area

180.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

354

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

-0.4

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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