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名称

CDK12-IN-3

英文名称

CDK12-IN-3

货号

C647924-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

CDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC 50 of 491 nM in enzymatic assay. In Vitro CDK12-IN-3 is a highly selective CDK12 inhibitor. CDK12-IN-3 (0.1 μM) shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells.. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CDK12 491 nM (IC 50 )

生化机理

CDK12-IN-3 是一种强效、选择性 CDK12 抑制剂，在酶促实验中的 IC 50 为 491 nM。

CAS号

2220184-50-7

分子式

C23H28F2N8O

分子量

470.52 g/mol

PubChem编号

134691746

Isomeric SMILES

CC(C)N1C=NC2=C(N=C(N=C21)N3CCCC[C@H]3CCO)NCC4=NC5=C(N4)C=CC(=C5F)F

IIUPAC Name

2-[(2S)-1-[6-[(4,5-difluoro-1H-benzimidazol-2-yl)methylamino]-9-propan-2-ylpurin-2-yl]piperidin-2-yl]ethanol

INCHI

1S/C23H28F2N8O/c1-13(2)33-12-27-20-21(26-11-17-28-16-7-6-15(24)18(25)19(16)29-17)30-23(31-22(20)33)32-9-4-3-5-14(32)8-10-34/h6-7,12-14,34H,3-5,8-11H2,1-2H3,(H,28,29)(H,26,30,31)/t14-/m0/s1

InChi Key

KULPPFCRBINTBS-AWEZNQCLSA-N

Smiles

CC(C)N1C=NC2=C(N=C(N=C21)N3CCCCC3CCO)NCC4=NC5=C(N4)C=CC(=C5F)F

溶解性

DMSO : 250 mg/mL (531.33 mM; Need ultrasonic)

Reaxy-Rn

62165380

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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