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Product details

名称

(S)-Carvedilol

分子类型

小分子

别名

(S)-卡维地洛

英文别名

(2s)-1-(9h-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol | BDBM50167072 | (S)-BM 14190 | AS-82016 | AKOS030255655 | S-(-)-Carvedilol | E78791 | GW13D96IND | UNII-GW13D96IND | Q27279308 | Carvedilol, (-)- | DTXSID50241749 | (S)-(-)-Carv

英文名称

(S)-Carvedilol

货号

C648448-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

(S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX) In Vitro The β-receptor blocking activity of (S)-Carvedilol is about 100 times greater than that of (R)-Carvedilol, whereas both enantiomers show equipotent potency as α-blockers. (S)-Carvedilol significantly attenuates Doxorubicin (DOX)-induced cell death, apoptotic morphological changes, decrease the mitochondrial membrane potential and oxidative stress responses by increasing the superoxide dismutase and catalase activities, and decreasing malondialdehyde contents and reactive oxygen species levels via the PI3K/AKT/eNO synthase pathway in vitro. (S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:β/α-1 adrenergic receptor

生化机理

(S)-卡维地洛是卡维地洛的 S-对映体，是一种非选择性 β/α-1 阻滞剂。(S)-卡维地洛对多柔比星（DOX）的血管或心脏毒性具有保护作用。

CAS号

95094-00-1

分子式

C24H26N2O4

分子量

406.47 g/mol

PubChem编号

185395

Isomeric SMILES

COC1=CC=CC=C1OCCNC[C@@H](COC2=CC=CC3=C2C4=CC=CC=C4N3)O

IIUPAC Name

(2S)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol

INCHI

1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3/t17-/m0/s1

InChi Key

OGHNVEJMJSYVRP-KRWDZBQOSA-N

Smiles

COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O

溶解性

DMSO : 200 mg/mL (492.04 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

406.189 Da

单同位素质量Monoisotopic Mass

406.189 Da

拓扑极表面积Topological Polar Surface Area

75.700 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

508.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.200

Reaxy-Rn

1514452

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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