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Product details

名称

CDE-096

英文名称

CDE-096

货号

C649438-5mg

包装规格

5mg

浓度

≥98%

储存温度

2-8°C储存,避光,干燥

运输条件

冰袋运输

产品介绍

CDE-096 is a potent inhibitor of PAI-1. CDE-096 prevents PAI-1 from inactivating tPA and uPA with similar potency ( IC 50 =30 and 25 nM, respectively) and is active against glycosylated PAI-1 , as well as PAI-1 derived from several species (IC 50 =19, 22 and 18 nM for murine, rat, and Porcine PAI-1 , respectively). In Vitro CDE-096 is active against both free PAI-1 and vitronectin-bound PAI-1. CDE-096 binds to PAI-1 with nanomolar affinity and induces conformational changes that prevent binding to both proteases and vitronectin. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

CDE-096 是 PAI-1 的强效抑制剂。CDE-096 以相似的效力阻止 PAI-1 使 tPA 和 uPA 失活（IC 50 =30 和 25 nM），并对糖基化的 PAI-1 以及来自多个物种的 PAI-1 有活性（IC 50 =19、22、25 nM）。

CAS号

1228357-04-7

分子式

C25H20F3NO12

分子量

583.42 g/mol

PubChem编号

59350299

Isomeric SMILES

C1=CC(=CC(=C1)OC(=O)NCC(COC(=O)C2=CC(=C(C(=C2)O)O)O)OC(=O)C3=CC(=C(C(=C3)O)O)O)C(F)(F)F

IIUPAC Name

[3-[[3-(trifluoromethyl)phenoxy]carbonylamino]-2-(3,4,5-trihydroxybenzoyl)oxypropyl] 3,4,5-trihydroxybenzoate

INCHI

1S/C25H20F3NO12/c26-25(27,28)13-2-1-3-14(8-13)41-24(38)29-9-15(40-23(37)12-6-18(32)21(35)19(33)7-12)10-39-22(36)11-4-16(30)20(34)17(31)5-11/h1-8,15,30-35H,9-10H2,(H,29,38)

InChi Key

OXWKLJPAKUDPJY-UHFFFAOYSA-N

Smiles

C1=CC(=CC(=C1)OC(=O)NCC(COC(=O)C2=CC(=C(C(=C2)O)O)O)OC(=O)C3=CC(=C(C(=C3)O)O)O)C(F)(F)F

PubChem CID

59350299

溶解性

DMSO : 100 mg/mL (171.40 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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