CCR6 inhibitor 1

CCR6 抑制剂 1

CCR6 inhibitor 1

C650442-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC 50 s of 0.45 and 6 nM for monkey and human CCR6 , much more selective at CCR6 over human CCR1 (IC 50 , > 30000 nM), and CCR7 (IC 50 , 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer In Vitro CCR6 inhibitor 1 (Compound 35) inhibits L20-induced human B cell migration. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Moneky CCR6 0.45 nM (IC 50 ) Human CCR6 6 nM (IC 50 ) Human CCR7 9400 nM (IC 50 )

CCR6 抑制剂 1 是一种强效的选择性 CCR6 抑制剂，对猴和人 CCR6 的 IC 50 s 分别为 0.45 和 6 nM，对 CCR6 的选择性远高于人 CCR1（IC 50 > 30000 nM）和 CCR7（IC 50 9400 nM）。CCR6 抑制剂 1 能明显阻断 ERK 磷酸化。

2437547-04-9

C24H23F3N4O3S

504.52 g/mol

O=S([C@H](CC1)CC[C@@H]1NC2=NC=C(C(F)(F)F)C=C2)(C3=CC=C(C4=CC=NC(C(N)=O)=C4)C=C3)=O

DMSO : ≥ 125 mg/mL (247.76 mM)