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Product details

名称

CARM1-IN-1

分子类型

小分子

英文名称

CARM1-IN-1

货号

C651239-5mg

包装规格

5mg

浓度

≥95%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM).IC50 value: 8.6 uM Target: CRAM1 inhibitorin vitro: CARM1-IN-1(Cmp 7g) displayed high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, 7g showed a significant dose-dependent reduction of the PSA promoter activity. Form:Solid

生化机理

CARM1-IN-1 是一种强效的特异性 CARM1（Coactivator-associated arginine methyltransferase 1）抑制剂，IC50 值为 8.6 uM；对 PRMT1 和 SET7 的活性很低（IC50 > 600 uM）。\nIC50 值：8.6 uM \nTarget：体外：CRAM1 抑制剂CARM1

CAS号

1020399-49-8

分子式

C26H21Br2NO3

分子量

555.26 g/mol

PubChem编号

24827559

Isomeric SMILES

C\1N(C/C(=C\C2=CC(=C(C=C2)O)Br)/C(=O)/C1=C/C3=CC(=C(C=C3)O)Br)CC4=CC=CC=C4

IIUPAC Name

(3E,5E)-1-benzyl-3,5-bis[(3-bromo-4-hydroxyphenyl)methylidene]piperidin-4-one

INCHI

1S/C26H21Br2NO3/c27-22-12-18(6-8-24(22)30)10-20-15-29(14-17-4-2-1-3-5-17)16-21(26(20)32)11-19-7-9-25(31)23(28)13-19/h1-13,30-31H,14-16H2/b20-10+,21-11+

InChi Key

KNMFTTWVELIVCC-CLVAPQHMSA-N

Smiles

C1C(=CC2=CC(=C(C=C2)O)Br)C(=O)C(=CC3=CC(=C(C=C3)O)Br)CN1CC4=CC=CC=C4

PubChem CID

24827559

溶解性

DMSO : ≥ 35 mg/mL (63.03 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

554.987 Da

单同位素质量Monoisotopic Mass

552.989 Da

拓扑极表面积Topological Polar Surface Area

60.800 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

670

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

5.8

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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