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名称

Corin

英文名称

Corin

货号

C651720-5mg

包装规格

5mg

浓度

≥98%

储存温度

2-8°C储存

运输条件

冰袋运输

产品介绍

Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC) , with a K i (inact) of 110 nM for LSD1 and an IC 50 of 147 nM for HDAC1 . In Vitro Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275, corin appears to more potently (Corin EC 50 95 nM vs. MS-275 EC 50 420 nM) and efficaciously induce cellular H3K9 acetylation. Interestingly, Corin (1 μM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 147 nM (HDAC1), Ki(inact): 110 nM (LSD1)

生化机理

Corin 是组蛋白赖氨酸特异性去甲基化酶 (LSD1) 和组蛋白去乙酰化酶 (HDAC) 的双重抑制剂，对 LSD1 的 K i (inact) 为 110 nM，对 HDAC1 的 IC 50 为 147 nM。

CAS号

1808113-09-8

分子式

C26H28N4O2

分子量

428.53 g/mol

PubChem编号

134828251

IIUPAC Name

4-[4-[4-[(1S,2R)-2-aminocyclopropyl]anilino]-4-oxobutyl]-N-(2-aminophenyl)benzamide

INCHI

1S/C26H28N4O2/c27-22-5-1-2-6-24(22)30-26(32)19-10-8-17(9-11-19)4-3-7-25(31)29-20-14-12-18(13-15-20)21-16-23(21)28/h1-2,5-6,8-15,21,23H,3-4,7,16,27-28H2,(H,29,31)(H,30,32)/t21-,23+/m0/s1

InChi Key

TYTLARZOLKJSJU-JTHBVZDNSA-N

Smiles

C1C(C1N)C2=CC=C(C=C2)NC(=O)CCCC3=CC=C(C=C3)C(=O)NC4=CC=CC=C4N

PubChem CID

134828251

溶解性

DMSO : 100 mg/mL (233.36 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

428.221 Da

单同位素质量Monoisotopic Mass

428.221 Da

拓扑极表面积Topological Polar Surface Area

110.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

625

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.8

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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