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Product details

名称

Chroman 1

别名

色满 1

英文名称

Chroman 1

货号

C654723-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 ( IC 50 =1 pM) than ROCK1 ( IC 50 =52 pM). Chroman 1 also has inhibitory activity against MRCK , with an IC 50 of 150 nM In Vitro Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 0-12 h or 24 h Result: Reduced the number of apoptotic cells, reduced caspase-3/7 activation. Western Blot AnalysisCell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 24 h Result: Partially inhibited caspase-3 activation. IC50& Target:ROCK2|1 pM (IC|50|)|ROCK1|52 pM (IC|50|)|MRCK|150 nM (IC|50|)

生化机理

Chroman 1 是一种高效、选择性的 ROCK 抑制剂。Chroman 1 对 ROCK2 的抑制作用（IC 50 =1 pM）强于 ROCK1（IC 50 =52 pM）。Chroman 1 对 MRCK 也有抑制活性，IC 50 为 150 nM。

CAS号

1273579-40-0(DMSO)

分子式

C24H28N4O4

分子量

436.50 g/mol

Smiles

O=C([C@@H]1COC2=CC=C(OC)C=C2C1)NC3=CC=C(C4=CNN=C4)C=C3OCCN(C)C

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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