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Product details

名称

CDK8-IN-1

英文名称

CDK8-IN-1

货号

C655866-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC 50 of 3 nM. In Vivo CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The t max is 0.25 h by PO. The mean values of C max are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:CDK8 3 nM (IC 50 )

生化机理

CDK8-IN-1 是一种强效、选择性 CDK8 抑制剂，其 IC 50 为 3 nM。

CAS号

1629633-48-2(DMSO)

分子式

C11H8F3N3O

分子量

255.20 g/mol

Smiles

C1=CN=CC=C1C2=CNC(=C2C(F)(F)F)C(=O)N

CMGC

包含CDK，MAPK，GSK3，CLK家族

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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