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Product details

名称

CARM1-IN-1

英文名称

CARM1-IN-1

货号

C656589-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM).IC50 value: 8.6 uM Target: CRAM1 inhibitorin vitro: CARM1-IN-1(Cmp 7g) displayed high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, 7g showed a significant dose-dependent reduction of the PSA promoter activity.

生化机理

CARM1-IN-1 是一种强效的特异性 CARM1（Coactivator-associated arginine methyltransferase 1）抑制剂，IC50 值为 8.6 uM；对 PRMT1 和 SET7 的活性很低（IC50 > 600 uM）。\nIC50 值：8.6 uM \nTarget：体外：CRAM1 抑制剂CARM1

CAS号

1020399-49-8(DMSO)

分子式

C26H21Br2NO3

分子量

555.26 g/mol

Smiles

C1C(=CC2=CC(=C(C=C2)O)Br)C(=O)C(=CC3=CC(=C(C=C3)O)Br)CN1CC4=CC=CC=C4

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

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