Corin

Corin

C656794-1ml

1ml

10mM in DMSO

充氩,-80℃储存

超低温冰袋运输

Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC) , with a K i (inact) of 110 nM for LSD1 and an IC 50 of 147 nM for HDAC1 . In Vitro Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275, corin appears to more potently (Corin EC 50 95 nM vs. MS-275 EC 50 420 nM) and efficaciously induce cellular H3K9 acetylation. Interestingly, Corin (1 μM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 147 nM (HDAC1), Ki(inact): 110 nM (LSD1)

Corin 是组蛋白赖氨酸特异性去甲基化酶 (LSD1) 和组蛋白去乙酰化酶 (HDAC) 的双重抑制剂，对 LSD1 的 K i (inact) 为 110 nM，对 HDAC1 的 IC 50 为 147 nM。

1808113-09-8(DMSO)

C26H28N4O2

428.53 g/mol

C1C(C1N)C2=CC=C(C=C2)NC(=O)CCCC3=CC=C(C=C3)C(=O)NC4=CC=CC=C4N