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Product details

名称

CP-547632 TFA

别名

CP-547632 三氟乙酸

英文名称

CP-547632 TFA

货号

C661611-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

充氩,干燥,-80℃储存

运输条件

超低温冰袋运输

产品介绍

CP-547632 TFA is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC 50 s of 11 nM and 9 nM, respectively. CP-547632 TFA is selective for VEGFR2 and bFGF over EGFR , PDGFRβ , and related tyrosine kinases (TKs). CP-547632 IC50& Target:VEGFR2 11 nM (IC 50 ) FGFR 9 nM (IC 50 ) In Vitro:CP-547632 TFA (1-1000 nM; 1 hours) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion, with an IC 50 value of 6 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot In Vivo:CP-547632 TFA (p.o.; 6.25-100mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts. CP-547632 TFA (oral; 50mg/kg; a single oral dose) yieldes plasma concentrations above 500 ng/ml for Biological Activity:CP-547632 TFA is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC 50 s of 11 nM and 9 nM, respectively. CP-547632 TFA is selective for VEGFR2 and bFGF over EGFR , PDGFRβ , and related tyrosine kinases (TKs). CP-547632

分子式

C22H25BrF5N5O5S

分子量

646.43 g/mol

Smiles

FC(F)(C(O)=O)F.O=C(NC1=C(C(N)=O)C(OCC2=C(F)C=C(Br)C=C2F)=NS1)NCCCCN3CCCC3

酪氨酸激酶

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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