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名称

伴刀豆球蛋白A 来源于洋刀豆（刀豆）

货号

C755090-5ml

包装规格

5ml

浓度

agarose conjugate, Type VI, saline suspension

产品介绍

伴刀豆球蛋白A（Con A）已用于酶的固定化。用于纯化含甘露糖的糖蛋白。应用：从刀豆（Canavalia ensiformis）中分离的伴刀豆球蛋白A（Con A）是甘露糖或葡萄糖特异性结合凝集素。凝集素是四聚体，每个亚基都具有糖结合位点。Con A可以通过葡萄聚糖亲和层析分离。 Concanavalin A (Con A), isolated from Jack beans ( Canavalia ensiformis ), is a mannose or glucose specific-binding lectin. The lectin is a tetramer and each subunit possesses a saccharide-binding site. Con A can be isolated by affinity chromatography with dextrans. Application: Concanavalin A (Con A) has been used for enzyme immobilization. Used for the purification of glycoproteins containing mannose

生化机理

伴刀豆球蛋白A（Con A）是一种T细胞有丝分裂原，可激活淋巴细胞。 Con A可通过自噬诱导肿瘤细胞死亡。刀豆素 A 无血型特异性，但对末端 α-D-甘露糖基和 α-D-葡糖基残基具有亲和力。需要 Ca 2+ 和 Mn 2+ 离子存在才能显示活性。刀豆素 A 在 pH 6.5 或更低的条件下解离为二聚体。pH 在 5.8 至 7.0 之间时，刀豆素 A 以四聚体形式存在；pH 高于 7.0 时，形成更高的聚合体。根据聚合程度不同，刀豆素 A 可能显示出具有促有丝分裂的活性。琥珀酰化可以生成一种能够在 pH 高于 5.6 时仍保持二聚体形式的活性二聚体。

Safety

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