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Product details

名称

DM4-SPDP

英文名称

DM4-SPDP

货号

D1373170-1mg

包装规格

1mg

储存温度

室温

运输条件

常规运输

产品介绍

DM4-SPDP 是由 linker SPDP 和毒性分子 DM4 连接而成的，可用来制备抗体偶联活性分子。DM4 是抑制细胞分裂的抗微管蛋剂。SPDP 是一种短链交联剂，可通过 NHS-酯和吡啶基二硫醇反应性基团与半胱氨酸巯基形成可降解 (cleavable) 的 (可还原的) 二硫键，实现胺与巯基的结合。 DM4-SPDP is a agent-linker conjugate composed of a potent antitubulin agent DM4 and a linker SMCC to make antibody agent conjugate. SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

分子式

C45H61ClN4O14S2

分子量

981.57 g/mol

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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