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Product introduction

DBCO-S-S-PEG3-biotin 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。DBCO-S-S-PEG3-biotin 是一种点击化学试剂。它含有 DBCO 基团，可以和含有 Azide 基团的分子发生环张力 (strain) 促进的炔-叠氮环加成反应 (SPAAC)。 DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. The hydrophilic spacer arm provides better solubility to the labeled molecules in aqueous media. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label.

Specs ⸢ View details ⸥

Chinese name

DBCO-S-S-PEG3-biotin

English name

DBCO-S-S-PEG3-biotin

Chinese alias

N-[24-(11,12-二脱氧二苯并[b,f]吖辛因-5(6H)-基)-13,21,24-三氧代-3,6,9-三氧杂-16,17-二硫杂-12,20-二氮杂二十四烷-1-基]-5-[(3aS,4S,6aR)-2-氧代六氢-1H-噻吩并[3,4-d]咪唑-4-基]戊酰胺

English alias

Dibenzocyclooctyne-S-S-PEG3-Biotin | N-[24-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-13,21,24-trioxo-3,6,9-trioxa-16,17-dithia-12,20-diazatetracos-1-yl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide

CAS number

1430408-09-5

molecular formula

C42H56N6O8S3

molecular weight

869.12 g/mol

Exact mass

≥95%

PSA

252.000 Å²

Logp

1.400

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