13,14-dihydro-15-keto前列腺素E2（13,14-dihydro-15-keto PGE2）是由15-羟基PGDH和15-oxo-PGδ13-还原酶生物合成的PGE2的代谢产物。该化合物积累到可检测的水平，然后进行进一步的代谢和化学分解，使其半衰期相对较短（〜9分钟），但比PGE2更长（〜2分钟），因此该化合物的累积量可观PGE2表达过程中的水平。受体结合研究表明，尽管前列腺素的代谢物通常以较低的亲和力与EP受体结合，但它们仍可能在这些生化途径中发挥重要作用。 13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) is a metabolite of PGE2 biosynthesized by the enzymes 15-hydroxy PGDH and 15-oxo-PG δ13-reductase. This compound accumulates to detectable levels, and then undergoes further metabolism and chemical decomposition, giving it a relatively short half-life (~ 9 minutes), but that is longer than PGE2 (~ 2 minutes), allowing this compound to build up to appreciable levels during PGE2 expression. Receptor binding studies indicate that although metabolites of prostaglandins typically bind to EP receptors with lower affinity, they might still play an important role in these biochemical pathways.