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名称

D-myo-肌醇-2, 4, 5 -三磷酸钠盐

别名

Ins(2,4,5)P3 (钠盐) | 2,4,5-IP3 (钠盐)

英文别名

Ins(2,4,5)P3 (sodium salt) | 2,4,5-IP3 (sodium salt) | D-myo-inositol-2,4,5-tris(hydrogen phosphate), trisodium salt

英文名称

D-myo-Inositol-2,4,5-triphosphate sodium salt

货号

D378587-100μg

包装规格

100μg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

D-肌醇-2,4,5-三磷酸钠盐（通常称为IP3）是研究最多的InsP。IP3是细胞中由磷脂酶C（PLC）介导的磷脂酰肌醇-4,5-二磷酸水解产生的第二信使。Ins（1,4,5）P3与其在内质网上的受体的结合导致钙通道的开放和细胞内钙的增加。 The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals. The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, D-myo-Inositol-2,4,5-triphosphate (sodium salt) (Ins(1,4,5)P3), more commonly referred to as IP3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.3,4 Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(2,4,5)P3 is a metabolically stable analog of Ins(1,4,5)P3 that is commonly used to study Ca2+ signaling pathways. Ins(2,4,5)P3 acts as a partial agonist at rat hepatic IP3 receptors, exhibiting 65% of the maximal Ca2+ response obtained with Ins(1,4,5)P3.

分子式

C₆H₁₂O₁₅P₃・3Na

分子量

486.04 g/mol

Smiles

[C@@H]1([C@@H]([C@H]([C@@H]([C@H]([C@@H]1O[P](O[H])([O-])=O)O[H])O[P](O[H])([O-])=O)O[P](O[H])(=O)[O-])O[H])O[H].[Na+].[Na+].[Na+]

Safety

「No Dangerous Attributes」

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